Author(s): M. Sai Nikitha, M. Veena, M. Sneha, M. Sai Sreeya, M. Durga Prerana, D. Sunitha, M. Sudhakar

Email(s): basasunitha@gmail.com

DOI: 10.52711/2454-2687.2026.00006   

Address: M. Sai Nikitha2, M. Veena2, M. Sneha2, M. Sai Sreeya2, M. Durga Prerana2, D. Sunitha1*, M. Sudhakar2
1Professor, Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Osmania University, Telangana, India.
2Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Osmania University, Telangana, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2026


ABSTRACT:
Millions of fatalities worldwide are caused by drug addiction each year. Still, widespread beliefs about its management as a chronic illness cast a shadow. In fact, people who use drugs are frequently called "weak," "immoral," or "depraved." As a result, drug addiction is frequently seen as a personal issue rather than a social one. According to technical definitions, drug addiction is a chronic, recurrent illness brought on by long-term drug effects on the brain. The term "drug dependence" refers to a mental and physical state in which a person exhibits behavioral and other reactions that lead to a compulsion to use a drug continuously or occasionally in order to feel its psychological effects and, occasionally, to avoid the discomfort of its absence1. In this review, we summarize the basic research's contribution to our knowledge of drug addiction and how it may lead to new treatments. Drug abuse is prevalent in those who suffer from psychiatric conditions like: Frank psychoses, psychopathic states, psychoneurosis, and excessively long-term use of medications for medical purposes (e.g., sedatives, analgesics, etc)2.


Cite this article:
M. Sai Nikitha, M. Veena, M. Sneha, M. Sai Sreeya, M. Durga Prerana, D. Sunitha, M. Sudhakar. Drug Addiction and Drug Dependence: A Review. International Journal of Reviews and Research in Social Sciences. 2026; 14(1):33-8. doi: 10.52711/2454-2687.2026.00006

Cite(Electronic):
M. Sai Nikitha, M. Veena, M. Sneha, M. Sai Sreeya, M. Durga Prerana, D. Sunitha, M. Sudhakar. Drug Addiction and Drug Dependence: A Review. International Journal of Reviews and Research in Social Sciences. 2026; 14(1):33-8. doi: 10.52711/2454-2687.2026.00006   Available on: https://ijrrssonline.in/AbstractView.aspx?PID=2026-14-1-6


REFERENCES:
1.    Kranzler HR, Li TK. What is addiction? Alcohol Res Health. 2008; 31(2):93-5. 
2.    Grant JE, Potenza MN, Weinstein A, Gorelick DA. Introduction to behavioral addictions. Am J Drug Alcohol Abuse. 2010; 36(5): 233-41.
3.    Shaffer HJ, La Plante DA, LaBrie RA, Kidman RC, Donato AN, Stanton MV. Toward a syndrome model of addiction: multiple expressions, common etiology. Harv Rev Psychiatry. 2004; 12(6): 367-74. 
4.    Blum K, Oscar-Berman M, Demetrovics Z, Barh D, Gold MS. Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS). Mol Neurobiol. 2014; 50(3): 765-96. 
5.    Koob GF, Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology. 2001; 24(2):97-129. 
6.    Nestler EJ, Barrot M, Self DW. DeltaFosB: a sustained molecular switch for addiction. Proc Natl Acad Sci. 2001; 98(20): 11042-6. 
7.    Perrotti LI, Hadeishi Y, Ulery PG, Barrot M, Monteggia L, Duman RS, Nestler EJ. Induction of deltaFosB in reward-related brain structures after chronic stress. J Neurosci. 2004; 24(47): 10594-602.
8.    Sinha R. Chronic stress, drug use, and vulnerability to addiction. Ann N Y Acad Sci. 2008 Oct;1141: 105-30.
9.    Torres-Berrio A, Cuesta S, Lopez-Guzman S, Nava-Mesa MO. Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience. Front Psychol. 2018;9: 2639. 
10.    Harford TC, Grant BF, Yi HY, Chen CM. Patterns of DSM-IV alcohol abuse and dependence criteria among adolescents and adults: results from the 2001 National Household Survey on Drug Abuse. Alcohol Clin Exp Res. 2005; 29(5): 810-28. 
11.    GBD 2016 Alcohol and Drug Use Collaborators. The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Psychiatry. 2018; 5(12): 987-1012.
12.    Weaver MF, Hopper JA, Gunderson EW. Designer drugs: assessment and management. Addict Sci Clin Pract. 2015; 10(1): 8.
13.    Ray R. National survey on extent, pattern and trends of drug abuse in India. Ministry of Social Justice and Empowerment, New Delhi: Government of India and United Nations Office on Drugs and Crime. 2004.
14.    Reddy KS and Gupta PC. Tobacco control in India. New Delhi: Ministry of Health and Family Welfare, Government of India, 2004; 43-47. 
15.    Sachadev JS, Yakhmi, RS, and Sharma, K. Changing pattern of drug abuse among patients attending de-addiction centre at Faridkot. Indian journal of psychiatry. 2002; 44(4): 30.
16.    Shukla BRK.  Drinks and Durgs in a North Indian Village: An Anthropological Study. Ethnographic and Folk Culture Society. 1987.
17.    Drug Addiction: Current Trends and Management. The International Journal of Indian Psychology, 2014.
18.    Soltani MAT, Asgari M, Toghiri A. Effective life skills training to reduce risk factors and increase protective factors for adolescent substance abuse at the Centre for Rehabilitation and Education. Journal of Substance Abuse Addiction Research. 2013; 7: 149-160.
19.    Stewart D, Gossop M, Marsden J, Kidd T and Treacy S. Similarities in outcomes for men and women after drug misuse treatment: results from the National Treatment Outcome Research Study (NTORS). Drug and Alcohol Review. 2003; 22(1): 35-41. 
20.    Taheri Z, Amiri M, Hosseini M, Mohsenpour M, Davidson PM. Factors Affecting Tendency for Drug Abuse in People Attending Addiction Treatment Centers: A Quantitative Content Analysis. J Addict Res Ther. 2016; 7: 270.
21.    Tandon, T. (2015). Drug policy in India. IDPC briefing paper, February. United Kingdom, National Treatment Agency for Substance Misuse. (2010). Women in drug treatment: what the latest figures reveal, London.
22.    United Nations Office on Drugs and Crime. (2016). World Drug Report. Retrieved from https://www.unodc.org/doc/wdr2016/ WORLD DRUG REPORT 2016 web.pdf on 22 June 2017.
23.    US Department of Health and Human Services (2005). National survey on drug use and health. Rockville (MD): Substance Abuse and Mental Health Services Administration, Office of Applied Studies.

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